Celecoxib – effects of celebrex.
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In controlled clinical trialselevated BUN occurred more frequently in patients receiving CELEBREX compared with patients on placeboThis laboratory abnormality was also seen in patients who received comparator NSAIDs in these studiesThe clinical significance of this abnormality has not been established.
The effects of celecoxib on the pharmacokinetics and/or pharmacodynamics of glyburideketoconazolesee DRUG INTERACTIONSphenytoinand tolbutamide have been studied in vivo and clinically important interactions have not been found.
Celecoxib is a potent inhibitor of prostaglandin synthesis in vitroCelecoxib concentrations reached during therapy have produced in vivo effectsProstaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal modelsProstaglandins are mediators of inflammationSince celecoxib is an inhibitor of prostaglandin synthesisits mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Inhibition of PGE2 synthesis may lead to sodium and water retention through increased reabsorption in the renal medullary thick ascending loop of Henle and perhaps other segments of the distal nephronIn the collecting ductsPGE2 appears to inhibit water reabsorption by counteracting the action of antidiuretic hormone.
Shortness of breath or trouble breathing chest pain weakness in one part or side of your body slurred speech swelling of the face or throat.
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you will find some general facts about this medication but you are strongly recommended to consult your doctor first before you make up your mind to buy celebrex online form the virtual drug store you trust.