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Based on pharmacokinetic studiesno dosage adjustment of ZOLOFT is necessary when used in combination with cimetidineAdditionallyno dosage adjustment is required for diazepamlithiumatenololtolbutamidedigoxinand drugs metabolized by CYP3A4when ZOLOFT is administered concomitantlySee CLINICAL PHARMACOLOGY
The most common side effects in children and adolescents who take include abnormal increase in muscle movement or agitationnose bleedsurinary incontinenceaggressive reactionpossible slowed growth rateand weight changeYour child’s height and weight should be monitored during treatment with ZOLOFT.
Zoloft dosage depends on the condition being treatedZoloft may interact with nonsteroidal anti-inflammatory drugsNSAIDsother medicines that make you sleepysuch as cold or allergy medicinesedativesnarcoticssleeping pillsmuscle relaxersand medicines for seizures or anxietycimetidinedigoxinfentanyllinezolidlithiumStJohn’s worttramadol5-hydroxytryptophanvalproateblood thinnerscough and cold medicinesother antidepressantsheart rhythm medicationsor migraine headache medicinesTell your doctor all medications and supplements you useZoloft use during pregnancy may lead to adverse effects in the newbornIt is unknown if Zoloft passes into breast milkConsult your doctor before breastfeedingIn some patientsif Zoloft is discontinued abruptlywithdrawal side effects include abdominal crampsflu-like symptomsfatigueand memory impairment.
Table 2Risk Differences of the Number of Cases of Suicidal Thoughts or Behaviors in the Pooled Placebo-Controlled Trials of Antidepressants in Pediatric and Adult Patients.
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